Prostate tumor diagnosis
Wake Forest University Health Sciences Rövid összefoglaló This randomized pilot clinical trial studies how well propranolol hydrochloride works in treating patients with prostate cancer who are undergoing surgery. When stressed, the body makes a molecule that may prevent prostate tumor diagnosis cells from dying, and propranolol hydrochloride may affect the signals in cells that cause tumor cells survival and death.
To determine plasma propranolol levels in individuals taking propranolol two hours after administration prior to prostatectomy. To determine if plasma prostate tumor diagnosis levels in men with prostate cancer can be used as a biomarker to identify patients who show activation of ADRB2 signaling pathway in prostate tumors.
To determine perceived stress level differences in men with prostate cancer prior to surgery to examine possible association between perceived stress level and catecholamine levels in blood and activation of ADRB2 pathway in tumors. To determine perceived distress level differences in men with prostate cancer prior to surgery to examine possible association between distress level and catecholamine levels in blood and activation of ADRB2 pathway tumors.
After completion of study treatment, patients are followed up for 30 days.